Date of Award
4-20-2010
Degree Type
Dissertation
Degree Name
Doctor of Philosophy (PhD)
Department
Chemistry
First Advisor
Dr. Binghe Wang - Committee Chair
Second Advisor
Dr. Shahab Shamsi - Committee Member
Third Advisor
Dr. Yujun Zheng - Committee Member
Abstract
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. In 2006, there were 559,888 cancer deaths in the US. Finding effective treatments for cancer is a major challenge among researchers. In solid tumor, hypoxia increases the progression of malignancy and metastasis by promoting angiogenesis. The transcription factor HIF-1 is responsible for the regulation of cellular processes, including glycolysis and angiogenesis. Clinical evidence has determined that expression of HIF-1 is strongly associated with poor patient prognosis. Also, activation of HIF-1 contributes to malignant behavior and therapeutic resistance. In view of these observations, there is a need for anti-cancer treatments that addresses hypoxic related tumors. HIF-1 presents a viable target for inhibition of tumor growth with small molecules. Herein, we describe the design and synthesis of small molecules that inhibit the HIF-1 pathway, as well as mechanistic studies involved in the investigation of the mode of action of these compounds.
Recommended Citation
Mooring, Suazette Reid, "Design, Synthesis and Mechanistic Studies of Small Molecule Inhibitors of the Hypoxia Inducible Factor Pathway" (2010). Chemistry Dissertations. Paper 40.
http://digitalarchive.gsu.edu/chemistry_diss/40